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Search Results for " vitamin d receptor "

23

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0200	Paricalcitol
	Paricalcitol 是一种 vitamin D receptor 激活剂，是一种 vitamin D 类似物，用于研究继发性甲状旁腺功能亢进，该疾病与慢性肾功能衰竭有关。
T16015	Maxacalcitol 马沙骨化醇,22-Oxacalcitriol	Others	Others
	Maxacalcitol (22-Oxacalcitriol) 是非血钙维生素 D3的一种类似物，是 VDR 样受体的配体。
T6430L	Calcifediol monohydrate 骨化二醇一水合物,25-hydroxy Vitamin D3 monohydrate	Endogenous Metabolite	Metabolism
	Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate) 是维生素 D3 在肝中经羟基化后得到的前激素，是有效的 VDR 抑制剂。
T14856	Calcipotriol MC 903,卡泊三醇,Calcipotriene
	Calcipotriol (MC 903) 是一种合成的 VitD3类似物，对维他命 D 受体具有高亲和力。
TQ0244	Calcipotriol monohydrate 钙泊三醇一水合物,卡泊三醇一水合物
	Calcipotriol monohydrate 是维生素 D3 的类似物，对维生素 D 受体具有高亲和力。Calcipotriol monohydrate 可用于银屑病研究。
T6374	Alfacalcidol Bondiol,Etalpha,阿法骨化醇,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol	Others	Others
	Alfacalcidol (Etalpha) 是一种维生素 D3 衍生物，是非选择性的维生素 D 受体活化剂，有用于骨质疏松研究的潜力。
T24166	Inecalcitol TX 522,TX-522,TX522,伊奈骨化醇	Apoptosis	Apoptosis
	Inecalcitol (TX 522) 是一种独特的维生素 D3 类似物，可诱导细胞凋亡，有抗癌活性。它是一种具有口服活性维生素 D 受体激动剂，Kd 为 0.53 nM。
T6112	Doxercalciferol TSA 840,度骨化醇,Hectorol,1.alpha.-Hydroxyvitamin D2,1α-hydroxyvitamin D2	Others	Others
	Doxercalciferol (TSA 840) 是一种维生素 D2 类似物，是一种维生素 D 受体激活剂，能够阻碍肾病的进程。
T19559	Seocalcitol EB 1089	Others	Others
	Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM).
T23762	Atocalcitol
	Atocalcitol is a vitamin D analog. It also acts as an agonist of alcitriol receptor.
T13197	trans-Doxercalciferol	Others	Others
	trans-Doxercalciferol is an isomer of Doxercalciferol. Doxercalciferol is an activator of the Vitamin D receptor and prevents renal disease.
T19227	Calcitriol Impurities A	Others	Others
	Calcitriol Impurities A refers to the contaminants found in Calcitriol, the hormonally active metabolite of vitamin D3, which serves to activate the vitamin D receptor.
T27825	LG190178 LG-190178,LG 190178
	LG190178, a vitamin D receptor (VDR) ligand, is a therapeutic agent used for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism.
T11643	Impurity B of Calcitriol 1β,25-Dihydroxyvitamin-D3,1-Epicalcitriol	Others	Others
	Impurity B of Calcitriol is an impurity of Calcitriol. Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).
T10663	Calcitriol-d6 Calcitriol D6,骨化三醇 D6	Others	Others
	Calcitriol D6 is the deuterated form of Calcitriol, which is the hormonally active form of vitamin D. Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor.
T75085	Doxercalciferol-d
	Doxercalciferol-d33是 Doxercalciferol 的氘化形式，是维生素 D2类似物，能作为维生素D 受体活化剂。
T11089	Doxercalciferol-D3	Others	Others
	Doxercalciferol-d3 is the deuterated form of Doxercalciferol and ACTS as vitamin D receptor activator (VDRA), which is a vitamin D2 analogue.
T35524	(1S)-Calcitriol
	(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion[1]. 3‐epi‐Calcitroic acid is an end product of (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3; 3‐epi‐1a,25(OH)2D3) metabolism by rat CYP24A1[1]. [1]. Steve Y Rhieu, et al. Metabolic stability of 3-epi-1α,25-dihydr...
T69676	LG190155
	LG190155 is a moderately potent VDR agonist. Vitamin D receptor (VDR) agonists are well known for their capacity to control calcium and bone metabolism and to regulate growth and differentiation of many cell types.
T24407	LG190119 LG-190119,LG 190119
	LG190119 is a nonsecosteroidal vitamin D receptor modulator. It effectively inhibited LNCaP xenograft tumor growth without increased serum calcium levels or any other apparent side effects. It also inhibits the growth of LNCaP xenograft tumors in athymic
T78944	VDR agonist 2
	VDR agonist 2（化合物16i）作为VDR（vitamin D receptor）激动剂，能有效抑制TGF-β1诱导的肝星状细胞（HSC）活化，并在体外和体内展现出显著的抗肝纤维化效果。
T36593	TEI-9648
	TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2]. TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 has cons...
T13292	VDR agonist 1	Others	Others
	VDR agonist 1 (compound 28) 是一种非甾体类维生素 D 受体 (VDR)的激动剂，在MCF-7 细胞中测得其IC50值为 690 nM。VDR agonist 1 通过上调 p21 和 p27 的表达来抑制细胞周期，通过增加 BAX 的表达来促进细胞凋亡，降低 Bcl-2 的表达，具有治疗乳腺癌的潜力。

化合物

Cat.No: TQ0200

Cat.No: T16015

Synonym: 马沙骨化醇,22-Oxacalcitriol

Target: Others

Calcifediol monohydrate

Cat.No: T6430L

Synonym: 骨化二醇一水合物,25-hydroxy Vitamin D3 monohydrate

Target: Endogenous Metabolite

Cat.No: T14856

Synonym: MC 903,卡泊三醇,Calcipotriene

Calcipotriol monohydrate

Cat.No: TQ0244

Synonym: 钙泊三醇一水合物,卡泊三醇一水合物

Cat.No: T6374

Synonym: Bondiol,Etalpha,阿法骨化醇,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol

Target: Others

Cat.No: T24166

Synonym: TX 522,TX-522,TX522,伊奈骨化醇

Target: Apoptosis

Doxercalciferol

Cat.No: T6112

Synonym: TSA 840,度骨化醇,Hectorol,1.alpha.-Hydroxyvitamin D2,1α-hydroxyvitamin D2

Target: Others

Cat.No: T19559

Synonym: EB 1089

Target: Others

Cat.No: T23762

trans-Doxercalciferol

Cat.No: T13197

Target: Others

Calcitriol Impurities A

Cat.No: T19227

Target: Others

Cat.No: T27825

Synonym: LG-190178,LG 190178

Impurity B of Calcitriol

Cat.No: T11643

Synonym: 1β,25-Dihydroxyvitamin-D3,1-Epicalcitriol

Target: Others

Cat.No: T10663

Synonym: Calcitriol D6,骨化三醇 D6

Target: Others

Doxercalciferol-d

Cat.No: T75085

Doxercalciferol-D3

Cat.No: T11089

Target: Others

(1S)-Calcitriol

Cat.No: T35524

Cat.No: T69676

Cat.No: T24407

Synonym: LG-190119,LG 190119

Cat.No: T78944

Cat.No: T36593

Cat.No: T13292

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1086	Vitamin D2 Calciferol,Ergocalciferol,Ercalciol,维生素D2	DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Vitamin D2 (Calciferol) 来源于植物或膳食补充剂，能够用作维生素 D 的补充剂。
T1135	Vitamin D3 维生素D3,Cholecalciferol,Colecalciferol	Endogenous Metabolite	Metabolism
	Vitamin D3 (Cholecalciferol) 是维生素 D 的一种天然存在形式，代谢激活后可以诱导细胞分化和癌细胞增殖。
T6430	Calcifediol 25-羟基维生素 D3,U 32070E,25-hydroxy Vitamin D3,RO 8-8892,骨化二醇	Endogenous Metabolite	Metabolism
	Calcifediol (U 32070E) 是由维生素 D3 在肝中经羟基化后得到的前激素，是 VDR 的有效抑制剂。
T6316	Calcitriol Topitriol,Rocaltrol,Calcijex,RO215535,骨化三醇,1,25-Dihydroxyvitamin D3	Endogenous Metabolite	Metabolism
	Calcitriol (1,25-Dihydroxyvitamin D3) 是一种维他命 D 的代谢物，一种维他命 D 受体 (VDR) 的激动剂 (IC50=0.4 nM)。Calcitriol 增加肠道对钙和磷的吸收，并与甲状旁腺激素一起增加了骨吸收。

天然产物

Cat.No: T1086

Synonym: Calciferol,Ergocalciferol,Ercalciol,维生素D2

Target: DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T1135

Synonym: 维生素D3,Cholecalciferol,Colecalciferol

Target: Endogenous Metabolite

Cat.No: T6430

Synonym: 25-羟基维生素 D3,U 32070E,25-hydroxy Vitamin D3,RO 8-8892,骨化二醇

Target: Endogenous Metabolite

Cat.No: T6316

Synonym: Topitriol,Rocaltrol,Calcijex,RO215535,骨化三醇,1,25-Dihydroxyvitamin D3

Target: Endogenous Metabolite

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